General Information

  • ID:  hor002937
  • Uniprot ID:  P22790
  • Protein name:  Cardio-excitatory peptide 1
  • Gene name:  NA
  • Organism:  Lissachatina fulica (Giant African land snail) (Achatina fulica)
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lissachatina (genus), Achatinidae (family), Achatinoidea (superfamily), Helicina, Stylommatophora (order), Eupulmonata (superorder), Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SGQSWRPQGRF
  • Length:  11(1-11)
  • Propeptide:  SGQSWRPQGRF
  • Signal peptide:  NA
  • Modification:  T11 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Potentiates the beat of the ventricle, and has also excitatory actions on the penis retractor muscle, the buccal muscle and the identified neurons controlling the buccal muscle movement of achatina.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002937_AF2.pdbhor002937_ESM.pdb

Physical Information

Mass: 148395 Formula: C57H84N20O16
Absent amino acids: ACDEHIKLMNTVY Common amino acids: GQRS
pI: 12.5 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -164.55 Boman Index: -4053
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 8405.45 Extinction Coefficient cystines: 5500
Absorbance 280nm: 550

Literature

  • PubMed ID:  8742492
  • Title:  Identifiable Achatina Giant Neurones: Their Localizations in Ganglia, Axonal Pathways and Pharmacological Features.
  • PubMed ID:  2322251
  • Title:   A novel cardio-excitatory peptide isolated from the atria of the African giant snail, Achatina fulica.